Perform drug concentration bioanalysis of siRNA and major metabolites by LC-MS(/MS) in support of PK and TK studies for multiple drug candidates.
Develop LC-MS(/MS) methods to support siRNA and major metabolites bioanalysis in a variety of biological matrices. Perform method qualification in house and support method transfer to external CRO.
Perform metabolite profiling of siRNA compounds by LC-MS(/MS), analyze and interpret resulting data in support of understanding siRNA drug metabolism.
Support LC-MS instruments operation and daily maintenance.
The successful candidate is expected to have the following qualifications:
Hands on experience in performing laboratory procedures and conducting experiments.
Experience with LC-MS methodologies and instrumentation.
Previous experience with quantification of analytes in biological samples using LC-MS is strongly preferred.
Previous experience with oligonucleotide is strongly preferred.
Previous experience with HRAM mass spectrometry and LIMS is a plus.
Working knowledge of Microsoft Office (Excel, Word, PowerPoint).
Ability to multi-task and work in a fast paced working environment.
Excellent interpersonal skills and a team player.z
A Master s or Bachelor s degree in biology, biochemistry, chemistry, or relevant field, with 1 year or 3 years of biopharmaceutical experience respectively.
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